Paper spray ionization mass spectrometry applied to forensic chemistry - drugs of abuse, inks and questioned documentsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ay01091e
With the advent of a new family of ionization techniques, ambient mass spectrometry (or ambient MS) was introduced as a simple way of generating ions in MS. Among them, the paper spray ionization (PS-MS) technique has demonstrated to be versatile to solve numerous problems in many areas of science....
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Main Authors | , , , , , , , , , , , |
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Format | Journal Article |
Language | English |
Published |
03.08.2017
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Online Access | Get full text |
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Summary: | With the advent of a new family of ionization techniques, ambient mass spectrometry (or ambient MS) was introduced as a simple way of generating ions in MS. Among them, the paper spray ionization (PS-MS) technique has demonstrated to be versatile to solve numerous problems in many areas of science. In this work, the PS-MS technique in the positive ionization mode (PS(+)-MS) was applied in two subareas of forensic chemistry: drugs of abuse and documentoscopy. In the first, the PS(+)MS technique was applied to obtain the chemical profiles of illicit drugs such as blotter papers containing 25I-NBOMe, extracts and leaves of natural cannabinoids (Δ
9
-tetrahydrocannabinol) and synthetic cannabinoids (naphthalen-1-yl-(1-butylindol-3-yl)methanone, (JWH-073);
n
-(adamantan-1-yl)-1-(4-fluorobutyl)-1
H
-indazole-3-carboxamide (5F-AKB48); 4-methyl-1-naphthyl-1-pentylindol-3-yl-methanone (JWH-122); 2-(2-methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone (JWH-250); and 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-210)) as well as to determine the authenticity in weight-loss herbal samples. Finally, an analytical method has been developed to quantify eight illicit drugs (3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-
N
-methylamphetamine (MDMA), 3,4-methylenedioxy-
N
-ethylamphetamine (MDEA),
meta
-chlorophenylpiperazine (
m
-CPP), methamphetamine (MA), cocaine, lysergic acid diethylamide (LSD), and dimethoxybromoamphetamine (DOB)) where their limit-of-detection ranged from 0.17 to 1 ppb, with linearity
R
2
> 0.99. The performance of the PS(+)-MS technique was also compared to other ionization sources: leaf spray mass spectrometry (LS-MS), and electrospray ionization mass spectrometry (ESI-MS). In the second part of this study, the PS(+)MS technique was successfully able to obtain the chemical profiles of different commercial blue pens. The relative intensity (RII
372
) of the methylene blue dye was monitored to discriminate crossings of traces, and to date questioned documents. The chemical profile of the second generation of Brazilian banknotes (R$, reais) was also explored. In general, the PS(+)-MS technique was proved to be an excellent analytical tool in forensic chemistry, acting like a "Swiss army knife".
Paper spray ionization mass spectrometry (PS-MS) technique is a versatile and powerful tool to solve numerous problems in forensic chemistry. |
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Bibliography: | 10.1039/c7ay01091e Electronic supplementary information (ESI) available. See DOI |
ISSN: | 1759-9660 1759-9679 |
DOI: | 10.1039/c7ay01091e |