Synthesis and antimalarial activity of novel bicyclic and tricyclic aza-peroxidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5ra16781g

• Main Authors: Yadav, Lalit, Tiwari, Mohit K, Kumar Shyamlal, Bharti Rajesh, Mathur, Manas, Swami, Ajit K, Puri, Sunil K, Naikade, Niraj K, Chaudhary, Sandeep
• Format: Journal Article
• Published: 01.03.2016

For the first time, novel bicyclic 5a-h as well as tricyclic 9a-h aza-peroxides were synthesized using a 1 O 2 -mediated photo-oxygenation methodology as a key step in 52-71% yields in which one of the oxygen atoms of the 1,2,4-trioxane ring has been replaced by a nitrogen atom. The methodology is s...