Efficient heterocyclisation by (di)terpene synthasesElectronic supplementary information (ESI) available: Experimental methods and structural data. See DOI: 10.1039/c5cc05754j

• Main Authors: Mafu, S, Potter, K. C, Hillwig, M. L, Schulte, S, Criswell, J, Peters, R. J
• Format: Journal Article
• Language: English
• Published: 18.08.2015

While cyclic ether forming terpene synthases are known, the basis for such heterocyclisation is unclear. Here it is reported that numerous (di)terpene synthases, particularly including the ancestral ent -kaurene synthase, efficiently produce isomers of manoyl oxide from the stereochemically appropri...