One-pot synthesis and evaluation of novel 3-aryl-6-ethoxycarbonyl-4-hydroxy-2H-pyran-2-one as a potent cytotoxic agentElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ra10015h

A series of new open chain analogs of Phelligridin J were synthesized by a clean one-pot approach. These compounds were evaluated for their in vitro cytotoxicity against normal and breast cancer cell lines. All the compounds exhibited potent cytotoxic activity in the lower micro molar range. Compoun...

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Main Authors Dhage, Ganesh Raosaheb, Thopate, Shankar Ramchandra, Ramteke, Shefali Nishikant, Kulkarni, Prasad Padmakar
Format Journal Article
LanguageEnglish
Published 04.11.2014
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Summary:A series of new open chain analogs of Phelligridin J were synthesized by a clean one-pot approach. These compounds were evaluated for their in vitro cytotoxicity against normal and breast cancer cell lines. All the compounds exhibited potent cytotoxic activity in the lower micro molar range. Compound 5o exhibited the maximum cytotoxic activity with IC 50 values of 12.49 and 13.76 μM, whereas compound 5a showed two-fold selectivity viz. IC 50 values of 21.80 to 43.40 μM against breast cancer (MCF7) and normal fibroblast (NIH3T3) cell lines, respectively. A series of new open chain analogs of Phelligridin J were synthesized and these compounds were found to be highly potent cytotoxic agents.
Bibliography:10.1039/c4ra10015h
Electronic supplementary information (ESI) available. See DOI
ISSN:2046-2069
DOI:10.1039/c4ra10015h