An integrated optofluidic device for single-cell sorting driven by mechanical propertiesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4lc01496k

We present a novel optofluidic device for real-time sorting on the basis of cell mechanical properties, measured by optical stretching. The whole mechanism, based on optical forces, does not hamper the viability of the tested cells, which can be used for further analysis. The device effectiveness is...

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Main Authors Yang, T, Paiè, P, Nava, G, Bragheri, F, Vazquez, R. Martinez, Minzioni, P, Veglione, M, Di Tano, M, Mondello, C, Osellame, R, Cristiani, I
Format Journal Article
LanguageEnglish
Published 16.02.2015
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Abstract We present a novel optofluidic device for real-time sorting on the basis of cell mechanical properties, measured by optical stretching. The whole mechanism, based on optical forces, does not hamper the viability of the tested cells, which can be used for further analysis. The device effectiveness is demonstrated by extracting a sample population enriched with highly metastatic cells from a heterogeneous cell mixture. Cell sorting based on mechanical properties is demonstrated using an optofluidic chip by extracting highly metastatic cells from a heterogeneous population.
AbstractList We present a novel optofluidic device for real-time sorting on the basis of cell mechanical properties, measured by optical stretching. The whole mechanism, based on optical forces, does not hamper the viability of the tested cells, which can be used for further analysis. The device effectiveness is demonstrated by extracting a sample population enriched with highly metastatic cells from a heterogeneous cell mixture. Cell sorting based on mechanical properties is demonstrated using an optofluidic chip by extracting highly metastatic cells from a heterogeneous population.
Author Vazquez, R. Martinez
Yang, T
Bragheri, F
Veglione, M
Nava, G
Osellame, R
Minzioni, P
Paiè, P
Cristiani, I
Mondello, C
Di Tano, M
AuthorAffiliation Università di Pavia
Dipartimento di Fisica
Dipartimento di Ingegneria Industriale e dell'Informazione
Istituto di Genetica Molecolare (IGM)-CNR
Istituto di Fotonica e Nanotecnologie (IFN)-CNR
Politecnico di Milano
AuthorAffiliation_xml – name: Istituto di Genetica Molecolare (IGM)-CNR
– name: Dipartimento di Fisica
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– name: Università di Pavia
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