Catalytic highly asymmetric 1,5(6)-selective cyclization reaction of -hydroxyimino cyclic ketones: direct approach to ring-fused hydroxyimino dihydropyransElectronic supplementary information (ESI) available. CCDC 931435. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3ob41001c
Herein, we have disclosed a catalytic asymmetric 1,5(6)-selective Michael/cyclization reaction of -hydroxyimino cyclic ketones with ,-unsaturated -keto esters. Unlike the previous catalytic strategies, this reaction provides a convenient 1,5(6)-selective asymmetric pathway to access synthetically us...
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Main Authors | , , , , |
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Format | Journal Article |
Language | English |
Published |
24.07.2013
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Online Access | Get full text |
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Summary: | Herein, we have disclosed a catalytic asymmetric 1,5(6)-selective Michael/cyclization reaction of -hydroxyimino cyclic ketones with ,-unsaturated -keto esters. Unlike the previous catalytic strategies, this reaction provides a convenient 1,5(6)-selective asymmetric pathway to access synthetically useful ring-fused dihydropyrans. In general, high levels of yield, enantio- and diastereoselectivity (up to 99% yield, >99% ee and >20:1 dr) were obtained.
Herein, we have disclosed an catalytic asymmetric 1,5(6)-selective Michael/cyclization reaction of -hydroxyimino cyclic ketones with ,-unsaturated -keto esters to access synthetic useful ring-fused dihydropyrans. |
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Bibliography: | Electronic supplementary information (ESI) available. CCDC For ESI and crystallographic data in CIF or other electronic format see DOI 10.1039/c3ob41001c 931435 |
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c3ob41001c |