Antitumor properties of a vanadyl(iv) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosisElectronic supplementary information (ESI) available. See DOI: 10.1039/c3dt50524c
Flavonoids, a polyphenolic compound family, and the vanadium compounds have interesting biological, pharmacological, and medicinal properties. We report herein the antitumor actions of the complex [VO(chrysin) 2 EtOH] 2 (VOchrys) on the MG-63 human osteosarcoma cell line. Oxovanadium( iv ), chrysin...
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Language | English |
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Abstract | Flavonoids, a polyphenolic compound family, and the vanadium compounds have interesting biological, pharmacological, and medicinal properties. We report herein the antitumor actions of the complex [VO(chrysin)
2
EtOH]
2
(VOchrys) on the MG-63 human osteosarcoma cell line. Oxovanadium(
iv
), chrysin and VOchrys caused a concentration-dependent inhibition of cell viability. The complex was the strongest antiproliferative agent (
p
< 0.05). Cytotoxicity and genotoxicity studies also showed a concentration effect. Reactive oxygen species (ROS) and the alterations in the GSH/GSSG ratio underlie the main mechanisms of action of VOchrys. Additions of ROS scavengers (vitamin C plus vitamin E) or GSH to the viability experiments demonstrated beneficial effects (
p
< 0.01). Besides, the complex triggered apoptosis, disruption of the mitochondria membrane potential (MMP), increased levels of caspase 3 and DNA fragmentation measured by the sub-G1 peak in cell cycle arrest experiments (
p
< 0.01). Collectively, VOchrys is a cell death modulator and a promissory complex to be used in cancer treatments.
Antitumor properties of a vanadium(
iv
) complex with chrysin were evaluated in MG-63 osteosarcoma cells, studied by cyto-, genotoxicity and apoptosis. |
---|---|
AbstractList | Flavonoids, a polyphenolic compound family, and the vanadium compounds have interesting biological, pharmacological, and medicinal properties. We report herein the antitumor actions of the complex [VO(chrysin)
2
EtOH]
2
(VOchrys) on the MG-63 human osteosarcoma cell line. Oxovanadium(
iv
), chrysin and VOchrys caused a concentration-dependent inhibition of cell viability. The complex was the strongest antiproliferative agent (
p
< 0.05). Cytotoxicity and genotoxicity studies also showed a concentration effect. Reactive oxygen species (ROS) and the alterations in the GSH/GSSG ratio underlie the main mechanisms of action of VOchrys. Additions of ROS scavengers (vitamin C plus vitamin E) or GSH to the viability experiments demonstrated beneficial effects (
p
< 0.01). Besides, the complex triggered apoptosis, disruption of the mitochondria membrane potential (MMP), increased levels of caspase 3 and DNA fragmentation measured by the sub-G1 peak in cell cycle arrest experiments (
p
< 0.01). Collectively, VOchrys is a cell death modulator and a promissory complex to be used in cancer treatments.
Antitumor properties of a vanadium(
iv
) complex with chrysin were evaluated in MG-63 osteosarcoma cells, studied by cyto-, genotoxicity and apoptosis. |
Author | Leon, I. E Porro, V Muglia, C. I Bollati-Fogolin, M Naso, L. G Di Virgilio, A. L Etcheverry, S. B Williams, P. A. M |
AuthorAffiliation | Centro de Química Inorgánica (CEQUINOR) Cátedra de Bioquímica Patológica Universidad Nacional de La Plata Facultad Ciencias Exactas Instituto Pasteur de Montevideo Facultad de Ciencias Exactas Laboratorio de Investigaciones del Sistema Inmune (LISIN) Unidad de Biología Celular |
AuthorAffiliation_xml | – name: Laboratorio de Investigaciones del Sistema Inmune (LISIN) – name: Instituto Pasteur de Montevideo – name: Facultad Ciencias Exactas – name: Universidad Nacional de La Plata – name: Facultad de Ciencias Exactas – name: Centro de Química Inorgánica (CEQUINOR) – name: Cátedra de Bioquímica Patológica – name: Unidad de Biología Celular |
Author_xml | – sequence: 1 givenname: I. E surname: Leon fullname: Leon, I. E – sequence: 2 givenname: A. L surname: Di Virgilio fullname: Di Virgilio, A. L – sequence: 3 givenname: V surname: Porro fullname: Porro, V – sequence: 4 givenname: C. I surname: Muglia fullname: Muglia, C. I – sequence: 5 givenname: L. G surname: Naso fullname: Naso, L. G – sequence: 6 givenname: P. A. M surname: Williams fullname: Williams, P. A. M – sequence: 7 givenname: M surname: Bollati-Fogolin fullname: Bollati-Fogolin, M – sequence: 8 givenname: S. B surname: Etcheverry fullname: Etcheverry, S. B |
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References_xml | – issn: 2009 volume-title: New developments in medicinal chemistry end-page: 105-129 publication-title: Medicinal Chemistry of Copper and Vanadium Bioactive Compounds doi: Etcheverry Williams – issn: 2011 issue: 25 end-page: 1996-2002 publication-title: Toxicol. in Vitro doi: Rodríguez-Mercado Mateos-Nava Altamirano-Lozano – issn: 1997 volume-title: IUPAC "Flavonoids (isoflavonoids and neoflavonoids)" publication-title: IUPAC Compendium of Chemical Terminology doi: McNaught Wilkinson – issn: 1995 issue: 31 end-page: 543-574 publication-title: Metal Ions in Biological Systems, Vanadium and Its Role in Life doi: Nielsen – issn: 2003 publication-title: Flavonoids in health and disease doi: Rice-Evans – issn: 1995 issue: 31 end-page: 595-616 publication-title: Metal Ions in Biological Systems, Vanadium and Its Role in Life doi: Djordjevic |
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Title | Antitumor properties of a vanadyl(iv) complex with the flavonoid chrysin [VO(chrysin)2EtOH]2 in a human osteosarcoma model: the role of oxidative stress and apoptosisElectronic supplementary information (ESI) available. See DOI: 10.1039/c3dt50524c |
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