Highly emissive deoxyguanosine analogue capable of direct visualization of B-Z transitionThis communication is dedicated to Professor Andrew D. Hamilton on the occasion of his 60th birthday.Electronic supplementary information (ESI) available. See DOI: 10.1039/c3cc48297a

• Main Authors: Park, Soyoung, Otomo, Haruka, Zheng, Linjie, Sugiyama, Hiroshi
• Format: Journal Article
• Language: English
• Published: 16.01.2014
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c3cc48297a

A 2-aminothieno[3,4- d ]pyrimidine G-mimic deoxyribonucleoside, th dG , was synthesized and incorporated readily into oligonucleotides as a versatile fluorescent guanine analogue. We demonstrate that th dG enables the visual detection of Z-DNA successfully based on different π-stacking of B- and Z-DNA. A 2-aminothieno[3,4- d ]pyrimidine G-mimic deoxyribonucleoside, th dG , was synthesized and incorporated readily into oligonucleotides as a versatile fluorescent guanine analogue. We demonstrate that th dG enables the visual detection of Z-DNA successfully based on different π-stacks of B- and Z-DNA.