Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydratesElectronic supplementary information (ESI) available: Synthetic procedures and physical characterization of products. See DOI: 10.1039/c3cc43458c

An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported. The utility of the method was demonstrated with the solid phase synthesis of a MUC1 fragment (20 mer) containing two glycosylation sites that were substituted with S-linked gly...

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Bibliographic Details
Main Authors Novoa, Alexandre, Barluenga, Sofia, Serba, Christelle, Winssinger, Nicolas
Format Journal Article
LanguageEnglish
Published 01.08.2013
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Summary:An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported. The utility of the method was demonstrated with the solid phase synthesis of a MUC1 fragment (20 mer) containing two glycosylation sites that were substituted with S-linked glycans. An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported.
Bibliography:Electronic supplementary information (ESI) available: Synthetic procedures and physical characterization of products. See DOI
10.1039/c3cc43458c
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc43458c