Detection of biomarkers with graphene nanoplatelets and nanoribbonsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3an01585h
Well-defined graphene nanosheets have become increasingly popular in the electrochemical detection and quantification of small molecules. In this work, the electrochemical oxidation of biomarkers such as uric acid, ascorbic acid, dopamine, NADH and DNA bases, namely guanine and adenine, was performe...
Saved in:
Main Authors | , , |
---|---|
Format | Journal Article |
Language | English |
Published |
03.02.2014
|
Online Access | Get full text |
Cover
Loading…
Abstract | Well-defined graphene nanosheets have become increasingly popular in the electrochemical detection and quantification of small molecules. In this work, the electrochemical oxidation of biomarkers such as uric acid, ascorbic acid, dopamine, NADH and DNA bases, namely guanine and adenine, was performed using cyclic voltammetry and differential pulse voltammetry to compare the electrochemical properties of electrochemically reduced nanoplatelets (ENPs) and electrochemically reduced nanoribbons (ENRs). The graphene materials displayed better electrochemical performances than the bare glassy carbon surface. Between the two graphene materials, the oxidation of biomarkers occurred at lower oxidation potentials on the ENP surface. The sensitivities of the two graphene surfaces varied when different biomarkers were studied. The ENP surface showed enhanced sensitivities for ascorbic acid, while the ENR surface exhibited higher sensitivities for uric acid and dopamine. As for the DNA bases analysed, both guanine and adenine were oxidised at lower potentials on the ENP surface than the ENR surface. The ENP surface displayed a better sensitivity for guanine, whereas the oxidation of adenine was more sensitive on the ENR surface.
Electrochemical analysis of uric acid, ascorbic acid, dopamine, NADH and DNA bases was performed on reduced graphene nanoplatelets and nanoribbons. |
---|---|
AbstractList | Well-defined graphene nanosheets have become increasingly popular in the electrochemical detection and quantification of small molecules. In this work, the electrochemical oxidation of biomarkers such as uric acid, ascorbic acid, dopamine, NADH and DNA bases, namely guanine and adenine, was performed using cyclic voltammetry and differential pulse voltammetry to compare the electrochemical properties of electrochemically reduced nanoplatelets (ENPs) and electrochemically reduced nanoribbons (ENRs). The graphene materials displayed better electrochemical performances than the bare glassy carbon surface. Between the two graphene materials, the oxidation of biomarkers occurred at lower oxidation potentials on the ENP surface. The sensitivities of the two graphene surfaces varied when different biomarkers were studied. The ENP surface showed enhanced sensitivities for ascorbic acid, while the ENR surface exhibited higher sensitivities for uric acid and dopamine. As for the DNA bases analysed, both guanine and adenine were oxidised at lower potentials on the ENP surface than the ENR surface. The ENP surface displayed a better sensitivity for guanine, whereas the oxidation of adenine was more sensitive on the ENR surface.
Electrochemical analysis of uric acid, ascorbic acid, dopamine, NADH and DNA bases was performed on reduced graphene nanoplatelets and nanoribbons. |
Author | Chua, Chun Kiang Pumera, Martin Lim, Chee Shan |
AuthorAffiliation | Division of Chemistry & Biological Chemistry Nanyang Technological University School of Physical and Mathematical Sciences |
AuthorAffiliation_xml | – name: School of Physical and Mathematical Sciences – name: Nanyang Technological University – name: Division of Chemistry & Biological Chemistry |
Author_xml | – sequence: 1 givenname: Chee Shan surname: Lim fullname: Lim, Chee Shan – sequence: 2 givenname: Chun Kiang surname: Chua fullname: Chua, Chun Kiang – sequence: 3 givenname: Martin surname: Pumera fullname: Pumera, Martin |
BookMark | eNqFjjFPwzAUhC1UJNLCwo702GBIceq6Kqw0iE4dyh69pC_E4DxbtgH1f_CDiSokBiSYTnff6XRjMWLHJMR5IaeFVLc3jUKWhV7q7khkhVrMc61ny5HIpJQqny30_ESMY3wZbCG1zMTnihI1yTgG10JtXI_hlUKED5M6eA7oO2ICRnbeYiJLKQLy7pAEU9eOY2mHheDYNBDfvLfUEycMezDcutDjYf2q3K6vAd_RWKwtTWFLBKvN-g5-fz8Vxy3aSGffOhEXD-XT_WMeYlP5YIaP--qnrv7nl3_xyu9a9QUr-GTq |
ContentType | Journal Article |
DOI | 10.1039/c3an01585h |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Chemistry |
EISSN | 1364-5528 |
EndPage | 18 |
ExternalDocumentID | c3an01585h |
ID | FETCH-rsc_primary_c3an01585h3 |
ISSN | 0003-2654 |
IngestDate | Thu May 19 04:17:20 EDT 2016 Thu May 30 17:32:00 EDT 2019 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-rsc_primary_c3an01585h3 |
Notes | 10.1039/c3an01585h Electronic supplementary information (ESI) available. See DOI |
PageCount | 9 |
ParticipantIDs | rsc_primary_c3an01585h |
PublicationCentury | 2000 |
PublicationDate | 20140203 |
PublicationDateYYYYMMDD | 2014-02-03 |
PublicationDate_xml | – month: 2 year: 2014 text: 20140203 day: 3 |
PublicationDecade | 2010 |
PublicationYear | 2014 |
SSID | ssj0001050 |
Score | 4.2472453 |
Snippet | Well-defined graphene nanosheets have become increasingly popular in the electrochemical detection and quantification of small molecules. In this work, the... |
SourceID | rsc |
SourceType | Enrichment Source Publisher |
StartPage | 172 |
Title | Detection of biomarkers with graphene nanoplatelets and nanoribbonsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3an01585h |
Volume | 139 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT8IwFG4UD3ox_iKCYnrwoCFDWdeNeSOAAUU9gAk30rFOSMggEzz4d_gH-7p2K4SZqJeFtGxZ8758fTz6fQ-hSyr-qwGkGD6jzLAcs2YwBmQY2IEP6YNVNW0hcH56ttuv1sOADnRBP1aXLLzK6DNTV_KfqMIYxFWoZP8Q2fShMACfIb5whQjD9VcxbvIFHyUpnxDSi7M2kRKsxVbUwGTlkIWz-RRySgiRdGQWI9HE8-C9WroNzrto8CkPk0dCDZjqGkUW2up1RAGBfbDJVKitKsAyvNx86cQlhVhVLyxFR4SFsPXXaFpl7sp2zY0xfL031lhsjJdMTizD8iOA9C1laSEJZUpIlDiDq8JE1YrPMpM1siWGaUuP6AqX_Epsy6BU6cETApZ2RgppdIVOq7Ktj9qZJVFvcH7m-tY9tPXkNtoxHZfSHNqpt_qdbrprQ555m3RXFC-dWNkS90bfDQlIlDSGiROQ_gHaV78ccF3C4BBt8fAI7TaShn3H6CuFA54FWMMBCzjgBA54DQ4Y4IAz4YDX4IBX4ICvAAzXWEMBAxQwQOEOb67lBJXuW_1G24AVDefS2mSop0ke5cJZyE8RdtjIdzmBrdGxrMAJPJ8T4noW8QkVRq8FlM9-RgEVsyeGcz8o_nTXGdrTcDpHuUW05CXI_BbehQraN8yKXjc |
link.rule.ids | 315,786,790,27955,27956 |
linkProvider | Royal Society of Chemistry |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Detection+of+biomarkers+with+graphene+nanoplatelets+and+nanoribbonsElectronic+supplementary+information+%28ESI%29+available.+See+DOI%3A+10.1039%2Fc3an01585h&rft.au=Lim%2C+Chee+Shan&rft.au=Chua%2C+Chun+Kiang&rft.au=Pumera%2C+Martin&rft.date=2014-02-03&rft.issn=0003-2654&rft.eissn=1364-5528&rft.volume=139&rft.issue=5&rft.spage=172&rft.epage=18&rft_id=info:doi/10.1039%2Fc3an01585h&rft.externalDocID=c3an01585h |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2654&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2654&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2654&client=summon |