CN-assisted oxidative cyclization of cyano cinnamates and styrene derivatives: a facile entry to 3-substituted chiral phthalidesElectronic supplementary information (ESI) available: Experimental details and spectral data of all the new compounds. See DOI: 10.1039/c2ob25409c

The asymmetric dihydroxylation (AD) of o -cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities. This unique reaction is characterized by unusual synergism between CN and osmate groups resulting in rate enhancement of the AD...

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Bibliographic Details
Main Authors Reddy, R. Santhosh, Kiran, I. N. Chaithanya, Sudalai, Arumugam
Format Journal Article
LanguageEnglish
Published 14.05.2012
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Summary:The asymmetric dihydroxylation (AD) of o -cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities. This unique reaction is characterized by unusual synergism between CN and osmate groups resulting in rate enhancement of the AD process. The method is amply demonstrated by the synthesis and the structural/stereochemical assignment of the natural products. The asymmetric dihydroxylation (AD) of o -cyano cinnamates and styrene derivatives leads to efficient construction of chiral phthalide frameworks in high optical purities. This unique reaction is characterized by unusual synergism between CN and osmate groups resulting in rate enhancement of the AD process.
Bibliography:10.1039/c2ob25409c
Electronic supplementary information (ESI) available: Experimental details and spectral data of all the new compounds. See DOI
ISSN:1477-0520
1477-0539
DOI:10.1039/c2ob25409c