Novel thalidomide analogues with potent NFκB and TNF expression inhibitionElectronic supplementary information (ESI) available: Experimental details. CCDC reference numbers 834073 and 834074. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c1md00184aCrystal data: Compound 9. C19H15N3O4, M = 349.34, monoclinic, space group P21/c, a = 8.0529(6), b = 16.0380(8), c = 12.8344(7) Å, β = 101.335(6)°, V = 1625.26(17) Å3, Z = 4, T = 100 K, μ = 0.103 mm−1, reflections

• Main Authors: Yeung, Sing Yee, Kampmann, Sven, Stubbs, Keith A, Skelton, Brian W, Kaskow, Belinda J, Abraham, Lawrence J, Stewart, Scott G
• Format: Journal Article
• Language: English
• Published: 01.11.2011

A series of N -phenyl thalidomide analogues have been prepared efficiently through a Buchwald-Hartwig cross coupling reaction as the key step. Several of these compounds have extraordinary TNF expression inhibition compared to both thalidomide and the current pharmaceutical agent Revlimid (Lenalidom...