Regioselective C-H bond functionalizations of acridines using organozinc reagentsThis article is part of the ChemComm 'Advances in catalytic C-C bond formation via late transition metals' web themed issue.Electronic supplementary information (ESI) available: Preparative and spectroscopic data. See DOI: 10.1039/c1cc16582h

Despite the recent advance in C-H bond functionalization chemistry, the C-H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C-H bonds adjacent to the ring nitrogen atom. Herein,...

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Bibliographic Details
Main Authors Hyodo, Isao, Tobisu, Mamoru, Chatani, Naoto
Format Journal Article
LanguageEnglish
Published 30.11.2011
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Summary:Despite the recent advance in C-H bond functionalization chemistry, the C-H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C-H bonds adjacent to the ring nitrogen atom. Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described. Regioselective C-H bond arylation and alkylation of acridines using organozinc reagents are described.
Bibliography:10.1039/c1cc16582h
Electronic supplementary information (ESI) available: Preparative and spectroscopic data. See DOI
This article is part of the
ChemComm
'Advances in catalytic C-C bond formation via late transition metals' web themed issue.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc16582h