Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy Dual stromal targeting in Pancreatic Cancer

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 163; no. 5; pp. 1267 - 1280.e7
• Main Authors: Blair, Alex B., Wang, Jianxin, Davelaar, John, Baker, Andrew, Li, Keyu, Niu, Nan, Wang, Junke, Shao, Yingkuan, Funes, Vanessa, Li, Pan, Pachter, Jonathan A., Maneval, Dan, Dezem, Felipe, Plummer, Jasmine, Chan, Keith Syson, Gong, Jun, Hendifar, Andrew E., Pandol, Stephen J., Burkhart, Richard, Zhang, Yuqing, Zheng, Lei, Osipov, Arsen
• Format: Journal Article
• Language: English
• Published: 17.06.2022

Simultaneous targeting of both intracellular and extracellular components of the stroma in pancreatic cancer, can alter the tumor microenvironment, thereby improving immunotherapy response.