Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy Dual stromal targeting in Pancreatic Cancer

Simultaneous targeting of both intracellular and extracellular components of the stroma in pancreatic cancer, can alter the tumor microenvironment, thereby improving immunotherapy response.

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Bibliographic Details
Published inGastroenterology (New York, N.Y. 1943) Vol. 163; no. 5; pp. 1267 - 1280.e7
Main Authors Blair, Alex B., Wang, Jianxin, Davelaar, John, Baker, Andrew, Li, Keyu, Niu, Nan, Wang, Junke, Shao, Yingkuan, Funes, Vanessa, Li, Pan, Pachter, Jonathan A., Maneval, Dan, Dezem, Felipe, Plummer, Jasmine, Chan, Keith Syson, Gong, Jun, Hendifar, Andrew E., Pandol, Stephen J., Burkhart, Richard, Zhang, Yuqing, Zheng, Lei, Osipov, Arsen
Format Journal Article
LanguageEnglish
Published 17.06.2022
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Summary:Simultaneous targeting of both intracellular and extracellular components of the stroma in pancreatic cancer, can alter the tumor microenvironment, thereby improving immunotherapy response.
Bibliography:Authors’ contributions
AB, JW, LZ, AO developed methodology. AB, JW, NN, AO, AB(Baker), VF, JD, KL, PL, YS, JP, DM, LZ, AO acquired data. AB, JW, AO, AB(Baker), FD JD, KC, YZ, JG, AH, SP, JP(Plummer), VF, RB, YS, LZ analyzed and interpreted data. Verastem provided critical materials. AB, KC, YZ, SP, LZ, AO wrote, reviewed, and/or revised the manuscript. LZ, JP, DM, AB, AO developed the concept and design the study. AO, LZ supervised the study.
ISSN:0016-5085
1528-0012
DOI:10.1053/j.gastro.2022.06.027