Liver transplantation in hemoglobin SC disease and autoimmune hepatitis: A case report
While liver transplantation (LT) is a life-saving measure for individuals with end-stage liver disease, the peri-operative management may be challenging in individuals with concomitant sickle cell disease (SCD). We report a case of a 50-year-old man with SCD genotype SC (HbSC) and cirrhosis secondar...
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| Published in | Experimental and clinical transplantation Vol. 20; no. 4; pp. 429 - 432 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
03.01.2022
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| Online Access | Get full text |
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| Abstract | While liver transplantation (LT) is a life-saving measure for individuals with end-stage liver disease, the peri-operative management may be challenging in individuals with concomitant sickle cell disease (SCD). We report a case of a 50-year-old man with SCD genotype SC (HbSC) and cirrhosis secondary to autoimmune hepatitis (AIH) who underwent LT. His post-operative course included upper extremity deep vein thrombosis (DVT), pulmonary embolus (PE), stroke via a patent foramen ovale after a line removal, and posterior reversible encephalopathy syndrome (PRES). Fortunately, he is alive with a functioning graft at 10 months after LT. This case highlights the feasibility of LT in SCD given the support of meticulous multidisciplinary care and the unique aspects of AIH and SCD for LT consideration. . |
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| AbstractList | While liver transplantation (LT) is a life-saving measure for individuals with end-stage liver disease, the peri-operative management may be challenging in individuals with concomitant sickle cell disease (SCD). We report a case of a 50-year-old man with SCD genotype SC (HbSC) and cirrhosis secondary to autoimmune hepatitis (AIH) who underwent LT. His post-operative course included upper extremity deep vein thrombosis (DVT), pulmonary embolus (PE), stroke via a patent foramen ovale after a line removal, and posterior reversible encephalopathy syndrome (PRES). Fortunately, he is alive with a functioning graft at 10 months after LT. This case highlights the feasibility of LT in SCD given the support of meticulous multidisciplinary care and the unique aspects of AIH and SCD for LT consideration. . |
| Author | Gurakar, Ahmet Chen, Po-Hung Weeks, Sharon Anders, Robert A. Garonzik-Wang, Jacqueline Chaturvedi, Shruti Oshima, Kiyoko Assarzadegan, Naziheh Kohli, Ruhail Kim, Ahyoung Lanzkron, Sophie |
| AuthorAffiliation | 1 Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA 3 Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA 2 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA 4 Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA |
| AuthorAffiliation_xml | – name: 2 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA – name: 1 Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA – name: 3 Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA – name: 4 Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA |
| Author_xml | – sequence: 1 givenname: Ahyoung surname: Kim fullname: Kim, Ahyoung organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 2 givenname: Naziheh surname: Assarzadegan fullname: Assarzadegan, Naziheh organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 3 givenname: Robert A. surname: Anders fullname: Anders, Robert A. organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 4 givenname: Kiyoko surname: Oshima fullname: Oshima, Kiyoko organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 5 givenname: Shruti surname: Chaturvedi fullname: Chaturvedi, Shruti organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 6 givenname: Sharon surname: Weeks fullname: Weeks, Sharon organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 7 givenname: Ruhail surname: Kohli fullname: Kohli, Ruhail organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 8 givenname: Sophie surname: Lanzkron fullname: Lanzkron, Sophie organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 9 givenname: Ahmet surname: Gurakar fullname: Gurakar, Ahmet organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 10 givenname: Jacqueline surname: Garonzik-Wang fullname: Garonzik-Wang, Jacqueline organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA – sequence: 11 givenname: Po-Hung surname: Chen fullname: Chen, Po-Hung organization: Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA Division of Transplant Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD USA |
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| Title | Liver transplantation in hemoglobin SC disease and autoimmune hepatitis: A case report |
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