Effect of Malnutrition on the Pharmacokinetics of Anti-tuberculosis Drugs in Ghanaian Children
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Published in | The international journal of tuberculosis and lung disease Vol. 25; no. 1; pp. 36 - 42 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.01.2021
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Online Access | Get full text |
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Author | Lartey, Margaret Dompreh, Albert Enimil, Anthony Peloquin, Charles A Kwara, Awewura Antwi, Sampson Lauzardo, Michael Wiesner, Lubbe Yang, Hongmei Hagan Seneadza, Nana Ayegua |
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AuthorAffiliation | 6 Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa 10 Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL 5 Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States 4 Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana 2 Department of Community Health, University of Ghana Medical School 3 Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana 1 Department of Epidemiology, University of Florida 7 Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 8 Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana 9 Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana |
AuthorAffiliation_xml | – name: 6 Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa – name: 10 Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – name: 2 Department of Community Health, University of Ghana Medical School – name: 3 Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana – name: 7 Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL – name: 4 Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana – name: 5 Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States – name: 8 Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana – name: 1 Department of Epidemiology, University of Florida – name: 9 Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana |
Author_xml | – sequence: 1 givenname: Nana Ayegua surname: Hagan Seneadza fullname: Hagan Seneadza, Nana Ayegua organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 2 givenname: Sampson surname: Antwi fullname: Antwi, Sampson organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 3 givenname: Hongmei surname: Yang fullname: Yang, Hongmei organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 4 givenname: Anthony surname: Enimil fullname: Enimil, Anthony organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 5 givenname: Albert surname: Dompreh fullname: Dompreh, Albert organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 6 givenname: Lubbe surname: Wiesner fullname: Wiesner, Lubbe organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 7 givenname: Charles A surname: Peloquin fullname: Peloquin, Charles A organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 8 givenname: Margaret surname: Lartey fullname: Lartey, Margaret organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 9 givenname: Michael surname: Lauzardo fullname: Lauzardo, Michael organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL – sequence: 10 givenname: Awewura surname: Kwara fullname: Kwara, Awewura organization: Department of Epidemiology, University of Florida Department of Community Health, University of Ghana Medical School Directorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana Department of Child Health, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa Deaprtment of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana Fevers Unit, Korle Bu Teaching Hospital, Accra, Ghana Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, FL |
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Notes | LW, CAP: Sample assays and PK analysis. NAHS, HY, CAP, ML, ML, AK: Analysis and interpretation of data. All authors were involved in drafting the paper and revising it critically for important intellectual content. All authors reviewed and approved the final version. NAHS, AK: Conception and study design. SA, AE, AD: Acquisition of data Author declaration of individual contribution |
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Title | Effect of Malnutrition on the Pharmacokinetics of Anti-tuberculosis Drugs in Ghanaian Children |
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