CRYO-ELECTRON MICROSCOPY RECONSTRUCTIONS OF THE PSEUDOMONAS AERUGINOSA AND NEISSERIA GONORRHOEAE TYPE IV PILI AT SUB-NANOMETER RESOLUTION

• Published in: Structure (London) Vol. 25; no. 9; pp. 1423 - 1435.e4
• Main Authors: Wang, Fengbin, Coureuil, Mathieu, Osinski, Tomasz, Orlova, Albina, Altindal, Tuba, Gesbert, Gaël, Nassif, Xavier, Egelman, Edward H., Craig, Lisa
• Format: Journal Article
• Language: English
• Published: 05.09.2017

We report here cryo-electron microscopy reconstructions of Type IV pili (T4P) from two important human pathogens, Pseudomonas aeruginosa and Neisseria gonorrhoeae , at ~ 8 Å and 5 Å resolution, respectively. The two structures reveal distinct arrangements of the pilin globular domains on the pilus s...