Detection of OG:A lesion mispairs by MutY relies on interactions of a single His residue with the 2-amino group of 8-oxoguanine

• Published in: Journal of the American Chemical Society Vol. 142; no. 31; pp. 13283 - 13287
• Main Authors: Lee, Andrea J., Majumdar, Chandrima, Kathe, Scott D., Van Ostrand, Robert P., Vickery, Holly R., Averill, April M., Nelson, Shane R., Manlove, Amelia H., McCord, Morgan A., David, Sheila S.
• Format: Journal Article
• Language: English
• Published: 23.07.2020

MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and prevent G to T transversion mutations. Successful repair requires MutY recognition of the OG:A mispair amidst highly abundant and structurall...