Development of Optimized Tissue Factor-Targeted Peptide Amphiphile Nanofibers to Slow Non-Compressible Torso Hemorrhage

• Published in: ACS nano Vol. 14; no. 6; pp. 6649 - 6662
• Main Authors: Klein, Mia K., Kassam, Hussein Aziz, Lee, Robert H., Bergmeier, Wolfgang, Peters, Erica B., Gillis, David C., Dandurand, Brooke R., Rouan, Jessica R., Karver, Mark R., Struble, Mark D., Clemons, Tristan D., Palmer, Liam C., Gavitt, Brian, Pritts, Timothy A., Tsihlis, Nick D., Stupp, Samuel I., Kibbe, Melina R.
• Format: Journal Article
• Language: English
• Published: 03.06.2020

Non-compressible torso hemorrhage accounts for a significant portion of preventable trauma deaths. We report here on the development of injectable, targeted supramolecular nanotherapeutics based on peptide amphiphile (PA) molecules that are designed to target tissue factor (TF) and, therefore, selec...