Significance of Minimal Residual Disease in Pediatric Mixed Phenotype Acute Leukemia: A Multi-Center Cohort Study

• Published in: Leukemia Vol. 34; no. 7; pp. 1741 - 1750
• Main Authors: Oberley, Matthew J., Raikar, Sunil S., Wertheim, Gerald B., Malvar, Jemily, Sposto, Richard, Rabin, Karen R., Punia, Jyotinder N., Seif, Alix E., Cahen, Viviane C., Schore, Reuven J., Luca, Dragos C., Guinipero, Terri, Woods, William G., O'Gorman, Maurice R.G., Orgel, Etan
• Format: Journal Article
• Language: English
• Published: 14.02.2020

The rarity of mixed phenotype acute leukemia (MPAL) has precluded adequate data to incorporate minimal residual disease (MRD) monitoring into therapy. Fluidity in MPAL classification systems further complicates understanding its biology and outcomes; this includes uncertainty surrounding the impact...