Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in COVID-19 Patients
Currently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) has been reported in almost all countries globally, and no effective therapy has been documented for COVID-19 and the role of convalescent plasma therapy is unknown. In current study, 6 COVID-19 subje...
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| Published in | The Journal of infectious diseases |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
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Oxford University Press
29.04.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Currently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) has been reported in almost all countries globally, and no effective therapy has been documented for COVID-19 and the role of convalescent plasma therapy is unknown. In current study, 6 COVID-19 subjects with respiratory failure received convalescent plasma at a median of 21.5 days after first detection of viral shedding, all tested negative for SARS-CoV-2 RNA by 3 days after infusion, and 5 died eventually. In conclusion, convalescent plasma treatment can discontinue SARS-CoV-2 shedding but cannot reduce mortality in critically end-stage COVID-19 patients, and treatment should be initiated earlier. |
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| AbstractList | Currently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) has been reported in almost all countries globally, and no effective therapy has been documented for COVID-19 and the role of convalescent plasma therapy is unknown. In current study, 6 COVID-19 subjects with respiratory failure received convalescent plasma at a median of 21.5 days after first detection of viral shedding, all tested negative for SARS-CoV-2 RNA by 3 days after infusion, and 5 died eventually. In conclusion, convalescent plasma treatment can discontinue SARS-CoV-2 shedding but cannot reduce mortality in critically end-stage COVID-19 patients, and treatment should be initiated earlier. |
| Author | Xu, Jiang-Hai Zhang, Zhi-Hao Wang, Ze-Shuai Lin, Wan-Bao Li, Cheng Zhang, Guo-Fan Zeng, Qing-Lei Zhang, Min-Min Cui, Guang-Lin Gou, Jian-Jun Li, Guang-Ming Ma, Shu-Huan Liu, Zhang-Suo Yu, Zu-Jiang |
| AuthorAffiliation | 1 Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City 3 The Department of Infectious Diseases, The First Affiliated Hospital of Nanyang Medical College, Nanyang City 6 Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City 2 Department of Infectious Diseases, The Sixth People’s Hospital of Zhengzhou City, Zhengzhou City 5 The Department of Infectious Diseases, Xinyang Central Hospital, Xinyang City 7 Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, all in Henan Province, China 4 The Department of Infectious Diseases, The Fifth People’s Hospital of Anyang City, Anyang City |
| AuthorAffiliation_xml | – name: 7 Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, all in Henan Province, China – name: 1 Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City – name: 5 The Department of Infectious Diseases, Xinyang Central Hospital, Xinyang City – name: 6 Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City – name: 3 The Department of Infectious Diseases, The First Affiliated Hospital of Nanyang Medical College, Nanyang City – name: 2 Department of Infectious Diseases, The Sixth People’s Hospital of Zhengzhou City, Zhengzhou City – name: 4 The Department of Infectious Diseases, The Fifth People’s Hospital of Anyang City, Anyang City |
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| Copyright | The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020 |
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| Title | Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in COVID-19 Patients |
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