Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9tx00149b

• Published in: Toxicology research (Cambridge) Vol. 8; no. 6; pp. 885 - 895
• Main Authors: Estrada-Ortiz, Natalia, Lopez-Gonzales, Elena, Woods, Ben, Stürup, Stefan, de Graaf, Inge A. M., Groothuis, Geny M. M., Casini, Angela
• Format: Journal Article
• Language: English
• Published: Royal Society of Chemistry 20.09.2019
• Subjects: Chemistry

Novel experimental anticancer gold-based compounds were studied for their mechanisms of toxicity in healthy rat kidney and liver tissues, using the Precision Cut Tissue Slices (PCTS) technique. Gold-based compounds are of great interest in the field of medicinal chemistry as novel therapeutic (antic...