Newly defined ABCB5+ dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin-1 receptor antagonist

• Published in: Stem cells (Dayton, Ohio) Vol. 37; no. 8; pp. 1057 - 1074
• Main Authors: BEKEN, SEPPE VANDER, DE VRIES, JULIANE C., MEIER-SCHIESSER, BARBARA, MEYER, PATRICK, JIANG, DONGSHENG, SINDRILARU, ANCA, FERREIRA, FILIPA F., HAINZL, ADELHEID, SCHATZ, SUSANNE, MUSCHHAMMER, JANA, SCHEURMANN, NATALIE J., KAMPILAFKOS, PANAGIOTIS, SEITZ, ANDREAS M., DÜRSELEN, LUTZ, IGNATIUS, ANITA, KLUTH, MARK A., GANSS, CHRISTOPH, WLASCHEK, MEINHARD, SINGH, KARMVEER, MAITY, PALLAB, FRANK, NATASHA Y., FRANK, MARKUS H., SCHARFFETTER-KOCHANEK, KARIN
• Format: Journal Article
• Language: English
• Published: 13.05.2019

Here we report the beneficial effects of a newly identified dermal cell subpopulation expressing the ATP-binding cassette subfamily B member 5 (ABCB5) for the therapy of non-healing wounds. Local administration of dermal ABCB5 + -derived MSCs attenuated macrophage-dominated inflammation and thereby...