Treg cell control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair Follicle Stem Cell Differentiation into Epithelial Cells for Skin Barrier Repair

• Published in: Immunity (Cambridge, Mass.) Vol. 50; no. 3; pp. 655 - 667.e4
• Main Authors: Mathur, Anubhav N., Zirak, Bahar, Boothby, Ian C., Tan, Madge, Cohen, Jarish N., Mauro, Thea M., Mehta, Pooja, Lowe, Margaret, Abbas, Abul K., Ali, Niwa, Rosenblum, Michael D.
• Format: Journal Article
• Language: English
• Published: 19.03.2019

Restoration of barrier tissue integrity after injury is dependent on the function of immune cells and stem cells (SCs) residing in the tissue. In response to skin injury, hair follicle stem cells (HFSCs), normally poised for hair generation, are recruited to the site of injury and differentiate into...