Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release

• Published in: Journal of allergy and clinical immunology Vol. 143; no. 4; pp. 1426 - 1443.e6
• Main Authors: Archer, Nathan K., Jo, Jay-Hyun, Lee, Steven K., Kim, Dongwon, Smith, Barbara, Ortines, Roger V., Wang, Yu, Marchitto, Mark C., Ravipati, Advaitaa, Cai, Shuting S., Dillen, Carly A., Liu, Haiyun, Miller, Robert J., Ashbaugh, Alyssa G., Uppal, Angad S., Oyoshi, Michiko, Malhotra, Nidhi, Hoff, Sabine, Garza, Luis A, Kong, Heidi H., Segre, Julia A., Geha, Raif S., Miller, Lloyd S.
• Format: Journal Article
• Language: English
• Published: 19.09.2018

Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis.