Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release
Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis.
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| Published in | Journal of allergy and clinical immunology Vol. 143; no. 4; pp. 1426 - 1443.e6 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
19.09.2018
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| Online Access | Get full text |
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| Abstract | Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis. |
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| AbstractList | Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis. |
| Author | Oyoshi, Michiko Marchitto, Mark C. Wang, Yu Liu, Haiyun Geha, Raif S. Ashbaugh, Alyssa G. Archer, Nathan K. Ravipati, Advaitaa Smith, Barbara Hoff, Sabine Lee, Steven K. Ortines, Roger V. Malhotra, Nidhi Miller, Lloyd S. Dillen, Carly A. Jo, Jay-Hyun Kim, Dongwon Miller, Robert J. Cai, Shuting S. Uppal, Angad S. Garza, Luis A Kong, Heidi H. Segre, Julia A. |
| AuthorAffiliation | 1 Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA 8 Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA 3 Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA 7 Department of Medicine, Division of Infectious Diseases 4 Division of Immunology, Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA 9 Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA 2 Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA 5 TRG Oncology III, Drug Discovery, Bayer AG, Berlin, Germany 6 Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA |
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Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA – sequence: 8 givenname: Mark C. surname: Marchitto fullname: Marchitto, Mark C. organization: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Division of Immunology, Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA TRG Oncology III, Drug Discovery, Bayer AG, Berlin, Germany Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Medicine, Division of Infectious Diseases, Department of 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MA, USA TRG Oncology III, Drug Discovery, Bayer AG, Berlin, Germany Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Medicine, Division of Infectious Diseases, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA – sequence: 21 givenname: Julia A. surname: Segre fullname: Segre, Julia A. organization: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Division of Immunology, Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA TRG Oncology III, Drug Discovery, Bayer AG, Berlin, Germany Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Medicine, Division of Infectious Diseases, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA – sequence: 22 givenname: Raif S. surname: Geha fullname: Geha, Raif S. organization: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Division of Immunology, Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA TRG Oncology III, Drug Discovery, Bayer AG, Berlin, Germany Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Medicine, Division of Infectious Diseases, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA – sequence: 23 givenname: Lloyd S. surname: Miller fullname: Miller, Lloyd S. email: lloydmiller@jhmi.edu organization: Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Division of Immunology, Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA TRG Oncology III, Drug Discovery, Bayer AG, Berlin, Germany Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA Department of Medicine, Division of Infectious Diseases, Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA |
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| Notes | Author contributions: N.K.A., L.A.G., H.H.K., J.A.S., R.S.G. and L.S.M. designed research; N.K.A., J-H.J., S.K.L., D.K., B.S., R.V.O., Y.W., M.C.M., A.R., S.S.C., C.A.D., H.L., R.J.M., A.G.A., A.S.U., M.O., N.M. and S.H. performed research; L.A.G., J-H.J., H.H.K., J.A.S., R.S.G. contributed new reagents/analytic tools; N.K.A., J-H.J., L.A.G., H.H.K., J.A.S., R.S.G. and L.S.M. analyzed data; and N.K.A., H.H.K., J.A.S., R.S.G. and L.S.M. wrote the paper. Author contributions |
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| PublicationTitle | Journal of allergy and clinical immunology |
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| Snippet | Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient... |
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| Title | Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release |
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