Extrathymically generated regulatory T cells establish a niche for intestinal border-dwelling bacteria and affect physiologic metabolite levels

• Published in: Immunity (Cambridge, Mass.) Vol. 48; no. 6; pp. 1245 - 1257.e9
• Main Authors: Campbell, Clarissa, Dikiy, Stanislav, Bhattarai, Shakti K., Chinen, Takatoshi, Matheis, Fanny, Calafiore, Marco, Hoyos, Beatrice, Hanash, Alan, Mucida, Daniel, Bucci, Vanni, Rudensky, Alexander Y.
• Format: Journal Article
• Language: English
• Published: 29.05.2018

The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota i...