Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors12

• Published in: Translational oncology Vol. 11; no. 6; pp. 1301 - 1306
• Main Authors: Treger, Taryn D., Chagtai, Tasnim, Butcher, Robert, Cresswell, George D., Al-Saadi, Reem, Brok, Jesper, Williams, Richard D., Roberts, Chrissy, Luscombe, Nicholas M., Pritchard Jones, Kathy, Mifsud, William
• Format: Journal Article
• Language: English
• Published: Neoplasia Press 29.08.2018
• Subjects: Original article

BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-stage disease. Early identification of DAWT h...