A tRNA-derived small RNA regulates ribosome biogenesis

• Published in: Nature (London) Vol. 552; no. 7683; pp. 57 - 62
• Main Authors: Kim, Hak Kyun, Fuchs, Gabriele, Wang, Shengchun, Wei, Wei, Zhang, Yue, Park, Hyesuk, Roy-Chaudhuri, Biswajoy, Li, Pan, Xu, Jianpeng, Chu, Kirk, Zhang, Feijie, Chua, Mei-Sze, So, Samuel, Zhang, Qiangfeng Cliff, Sarnow, Peter, Kay, Mark A.
• Format: Journal Article
• Language: English
• Published: 29.11.2017

tRNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments (tRFs)) are an abundant class of small non-coding RNAs whose biological roles are not well defined. We show that inhibition of a specific tsRNA, LeuCAG3′tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-de...