A RENEWED MODEL OF PANCREAS CANCER EVOLUTION BASED ON GENOMIC REARRANGEMENT PATTERNS

• Published in: Nature (London) Vol. 538; no. 7625; pp. 378 - 382
• Main Authors: Notta, Faiyaz, Chan-Seng-Yue, Michelle, Lemire, Mathieu, Li, Yilong, Wilson, Gavin W, Connor, Ashton A, Denroche, Rob E, Liang, Sheng-Ben, Brown, Andrew MK, Kim, Jaeseung C, Wang, Tao, Simpson, Jared T, Beck, Timothy, Borgida, Ayelet, Buchner, Nicholas, Chadwick, Dianne, Hafezi-Bakhtiari, Sara, Dick, John E, Heisler, Lawrence, Hollingsworth, Michael A, Ibrahimov, Emin, Jang, Gun Ho, Johns, Jeremy, Jorgensen, Lars GT, Law, Calvin, Ludkovski, Olga, Lungu, Ilinca, Ng, Karen, Pasternack, Danielle, Petersen, Gloria M, Shlush, Liran I, Timms, Lee, Tsao, Ming-Sound, Wilson, Julie M, Yung, Christina K, Zogopoulos, George, Bartlett, John MS, Alexandrov, Ludmil B, Real, Francisco X, Cleary, Sean P, Roehrl, Michael H, McPherson, John D, Stein, Lincoln D, Hudson, Thomas J, Campbell, Peter J, Gallinger, Steven
• Format: Journal Article
• Language: English
• Published: 12.10.2016

Pancreas cancer (PC), a highly aggressive tumour type with uniformly poor prognosis, is an exemplar of the classical view of cancer development based on stepwise progression 1 . The current progression model, based on analyses of precursor lesions termed pancreatic intraepithelial neoplasm (PanINs)...