Development of a facile antibody–drug conjugate platform for increased stability and homogeneity† †Electronic supplementary information (ESI) available: Synthetic schemes and characterization data, experimental procedures, Fig. S1 and S2. See DOI: 10.1039/c6sc05149a Click here for additional data file

• Published in: Chemical science (Cambridge) Vol. 8; no. 3; pp. 2387 - 2395
• Main Authors: Gupta, Nimish, Kancharla, Johny, Kaushik, Shelly, Ansari, Aasif, Hossain, Samad, Goyal, Ravinder, Pandey, Manoj, Sivaccumar, Jwala, Hussain, Sazid, Sarkar, Arindam, Sengupta, Aniruddha, Mandal, Swadhin K., Roy, Monideepa, Sengupta, Shiladitya
• Format: Journal Article
• Language: English
• Published: Royal Society of Chemistry 09.12.2016
• Subjects: Chemistry

Pt( ii )-based linkers re-bridge the antibody chains via strong Pt–S interaction thereby imparting homogeneity, site-specificity and stability to the antibody–drug conjugate. Despite the advances in the design of antibody–drug conjugates (ADCs), the search is still ongoing for novel approaches that...