Rules of Engagement: The Type VI Secretion System in V. cholerae
Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins. Vibrio c...
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| Published in | Trends in microbiology (Regular ed.) Vol. 25; no. 4; pp. 267 - 279 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
24.12.2016
|
| Online Access | Get full text |
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| Abstract | Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins.
Vibrio cholerae
is a Gram-negative pathogen that can use its T6SS during antagonistic interactions with neighboring prokaryotic and eukaryotic competitors. The T6SS not only promotes
V. cholerae
's survival during its aquatic and host life cycles, but also influences its evolution by facilitating horizontal gene transfer. This review details the recent insights regarding the structure and function of the T6SS as well as the diverse signals and regulatory pathways that control its activation in
V. cholerae
. |
|---|---|
| AbstractList | Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins.
Vibrio cholerae
is a Gram-negative pathogen that can use its T6SS during antagonistic interactions with neighboring prokaryotic and eukaryotic competitors. The T6SS not only promotes
V. cholerae
's survival during its aquatic and host life cycles, but also influences its evolution by facilitating horizontal gene transfer. This review details the recent insights regarding the structure and function of the T6SS as well as the diverse signals and regulatory pathways that control its activation in
V. cholerae
. |
| Author | Joshi, Avatar Pukatzki, Stefan Yildiz, Fitnat H. Rogers, Andrew Teschler, Jennifer Kostiuk, Benjamin |
| AuthorAffiliation | a Department of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, California, USA c Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA b Department of Medical Microbiology and Immunology, University of Alberta, Alberta, Canada |
| AuthorAffiliation_xml | – name: b Department of Medical Microbiology and Immunology, University of Alberta, Alberta, Canada – name: a Department of Microbiology and Environmental Toxicology, University of Santa Cruz, Santa Cruz, California, USA – name: c Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA |
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| Title | Rules of Engagement: The Type VI Secretion System in V. cholerae |
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