HRQoL among Older Related HSC Donors (>60 yrs.) is Equivalent to that of Younger Related Donors (18–60 yrs.): An RDSafe Study

The increasing number of older adults with blood-related disorders and the introduction of reduced intensity conditioning regimens has led to increases in hematopoietic stem cell (HSC) transplantation among older adults and a corresponding increase in the age of siblings who donate HSCs to these pat...

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Published inBiology of blood and marrow transplantation Vol. 23; no. 1; pp. 165 - 171
Main Authors Switzer, Galen E., Bruce, Jessica, Kiefer, Deidre M., Kobusingye, Hati, Drexler, Rebecca, Besser, RaeAnne M., Confer, Dennis L., Horowitz, Mary M., King, Roberta J., Shaw, Bronwen E., Riches, Marcie, Hayes-Lattin, Brandon, Linenberger, Michael, Bolwell, Brian, Rowley, Scott D., Litzow, Mark R., Pulsipher, Michael A.
Format Journal Article
LanguageEnglish
Published 14.10.2016
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Abstract The increasing number of older adults with blood-related disorders and the introduction of reduced intensity conditioning regimens has led to increases in hematopoietic stem cell (HSC) transplantation among older adults and a corresponding increase in the age of siblings who donate HSCs to these patients. Data regarding the donation-related experiences of older donors is lacking. The Related Donor Safety Study (RDSafe) aimed to examine/compare health-related quality of life (HRQoL) of older versus younger HSC donors. 60 peripheral blood stem cell (PBSC) donors ages 18–60 and 104 PBSC donors age >60 completed validated questionnaires at pre-donation, 4 weeks and 1 year post-donation. Prior to donation, older donors had poorer general physical health (t=−3.27; p=.001) but better mental health (t=2.11; p<.05). There were no age differences in multiple other donation-related factors. At 4 weeks post-donation, there were no group differences in general physical/mental health, but older donors were less likely to report donation-related pain (t=−2.26; p<.05) and concerns (t=−3.38; p=.001). At both 4 weeks and 1 year post-donation, there were no significant differences in the percentage of each age group feeling physically back to normal or in the number of days it took donors to feel completely well. There was no evidence that increasing age within the older donor group was associated with poorer donation-related HRQoL. Taken together, these data support the current practice of HSC donation by sibling donors above age 60, providing no evidence of worsening HRQoL up to one year after donation in individuals up to age 76.
AbstractList The increasing number of older adults with blood-related disorders and the introduction of reduced intensity conditioning regimens has led to increases in hematopoietic stem cell (HSC) transplantation among older adults and a corresponding increase in the age of siblings who donate HSCs to these patients. Data regarding the donation-related experiences of older donors is lacking. The Related Donor Safety Study (RDSafe) aimed to examine/compare health-related quality of life (HRQoL) of older versus younger HSC donors. 60 peripheral blood stem cell (PBSC) donors ages 18–60 and 104 PBSC donors age >60 completed validated questionnaires at pre-donation, 4 weeks and 1 year post-donation. Prior to donation, older donors had poorer general physical health (t=−3.27; p=.001) but better mental health (t=2.11; p<.05). There were no age differences in multiple other donation-related factors. At 4 weeks post-donation, there were no group differences in general physical/mental health, but older donors were less likely to report donation-related pain (t=−2.26; p<.05) and concerns (t=−3.38; p=.001). At both 4 weeks and 1 year post-donation, there were no significant differences in the percentage of each age group feeling physically back to normal or in the number of days it took donors to feel completely well. There was no evidence that increasing age within the older donor group was associated with poorer donation-related HRQoL. Taken together, these data support the current practice of HSC donation by sibling donors above age 60, providing no evidence of worsening HRQoL up to one year after donation in individuals up to age 76.
Author King, Roberta J.
Horowitz, Mary M.
Rowley, Scott D.
Litzow, Mark R.
Hayes-Lattin, Brandon
Drexler, Rebecca
Besser, RaeAnne M.
Bruce, Jessica
Kobusingye, Hati
Pulsipher, Michael A.
Kiefer, Deidre M.
Switzer, Galen E.
Confer, Dennis L.
Riches, Marcie
Linenberger, Michael
Shaw, Bronwen E.
Bolwell, Brian
AuthorAffiliation 1 Department of Medicine, University of Pittsburgh, Pittsburgh, PA
2 Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA
3 Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA
6 CIBMTR® (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
11 John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
5 CIBMTR® (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match®, Minneapolis, MN
10 Cleveland Clinic Lerner School of Medicine, Cleveland Clinic, Cleveland, OH
4 Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA
8 Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland OR
7 Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC
13
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Snippet The increasing number of older adults with blood-related disorders and the introduction of reduced intensity conditioning regimens has led to increases in...
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Title HRQoL among Older Related HSC Donors (>60 yrs.) is Equivalent to that of Younger Related Donors (18–60 yrs.): An RDSafe Study
URI https://pubmed.ncbi.nlm.nih.gov/PMC5182103
Volume 23
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