Post-transcriptional regulation of glycoprotein quality control in the endoplasmic reticulum is controlled by the E2 Ub-conjugating enzyme UBC6e

• Published in: Molecular cell Vol. 63; no. 5; pp. 753 - 767
• Main Authors: Hagiwara, Masatoshi, Ling, Jingjing, Koenig, Paul-Albert, Ploegh, Hidde L.
• Format: Journal Article
• Language: English
• Published: 25.08.2016

Endoplasmic reticulum-associated degradation (ERAD) is essential for protein quality control in the ER, not only when the ER is stressed, but also at steady state. We report a new layer of homeostatic control, in which ERAD activity itself is regulated post-transcriptionally and independently of the...