Pharmacodynamic markers and clinical results from the Phase II Study of the SMAC-Mimetic Birinapant in Women with Relapsed Platinum-Resistant or Refractory Epithelial Ovarian Cancer
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| Published in | Cancer Vol. 122; no. 4; pp. 588 - 597 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
13.11.2015
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| Online Access | Get full text |
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| Author | Figg, W. Douglas Lee, Jung-min Kinders, Robert J. Cao, Liang Peer, Cody J. Takebe, Naoko Herrmann, Michelle A. O’Sullivan, Ciara C. Noonan, Anne M. Bunch, Kristen P. Jordan, Elizabeth Annunziata, Christina M. Chen, Jin-Qiu Houston, Nicole Kohn, Elise C. |
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| AuthorAffiliation | 2 Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD 4 Cancer Therapy Evaluation Program, NCI, Shady Grove, MD 5 Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD 3 Collaborative Protein Technology Resource, NCI, Bethesda, MD 6 Cancer Genetics Branch, NCI, Bethesda, MD 1 Women’s Malignancies Branch, NCI, Bethesda, MD 7 Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD |
| AuthorAffiliation_xml | – name: 1 Women’s Malignancies Branch, NCI, Bethesda, MD – name: 7 Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – name: 5 Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD – name: 6 Cancer Genetics Branch, NCI, Bethesda, MD – name: 4 Cancer Therapy Evaluation Program, NCI, Shady Grove, MD – name: 2 Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD – name: 3 Collaborative Protein Technology Resource, NCI, Bethesda, MD |
| Author_xml | – sequence: 1 givenname: Anne M. surname: Noonan fullname: Noonan, Anne M. organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 2 givenname: Kristen P. surname: Bunch fullname: Bunch, Kristen P. organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 3 givenname: Jin-Qiu surname: Chen fullname: Chen, Jin-Qiu organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 4 givenname: Michelle A. surname: Herrmann fullname: Herrmann, Michelle A. organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 5 givenname: Jung-min surname: Lee fullname: Lee, Jung-min organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 6 givenname: Elise C. surname: Kohn fullname: Kohn, Elise C. organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 7 givenname: Ciara C. surname: O’Sullivan fullname: O’Sullivan, Ciara C. organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 8 givenname: Elizabeth surname: Jordan fullname: Jordan, Elizabeth organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 9 givenname: Nicole surname: Houston fullname: Houston, Nicole organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 10 givenname: Naoko surname: Takebe fullname: Takebe, Naoko organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 11 givenname: Robert J. surname: Kinders fullname: Kinders, Robert J. organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 12 givenname: Liang surname: Cao fullname: Cao, Liang organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 13 givenname: Cody J. surname: Peer fullname: Peer, Cody J. organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 14 givenname: W. Douglas surname: Figg fullname: Figg, W. Douglas organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD – sequence: 15 givenname: Christina M. surname: Annunziata fullname: Annunziata, Christina M. email: annunzic@mail.nih.gov organization: Women’s Malignancies Branch, NCI, Bethesda, MD Department of Gynecologic Oncology, Walter Reed National Military Medical Center, Bethesda, MD Collaborative Protein Technology Resource, NCI, Bethesda, MD Cancer Therapy Evaluation Program, NCI, Shady Grove, MD Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis, NCI, Frederick, MD Cancer Genetics Branch, NCI, Bethesda, MD Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, NCI, Bethesda, MD |
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| Notes | Current address: Division of Medical Oncology, The Ohio State University, Columbus, OH |
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| Title | Pharmacodynamic markers and clinical results from the Phase II Study of the SMAC-Mimetic Birinapant in Women with Relapsed Platinum-Resistant or Refractory Epithelial Ovarian Cancer |
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