Pro-metastatic NEDD9 regulates individual cell migration via caveolin-1-dependent trafficking of integrins

• Published in: Molecular cancer research Vol. 13; no. 3; pp. 423 - 438
• Main Authors: Kozyulina, Polina Y., Loskutov, Yuriy V., Kozyreva, Varvara K., Rajulapati, Anuradha, Ice, Ryan J., Jones, Brandon. C., Pugacheva, Elena N.
• Format: Journal Article
• Language: English
• Published: 15.10.2014

The dissemination of tumor cells relies on efficient cell adhesion and migration, which in turn depends upon endocytic trafficking of integrins. In the current work, it was found that depletion of pro-metastatic protein, NEDD9, in breast cancer (BC) cells results in a significant decrease in individ...