A Chaperome Sub-Network Safeguards Proteostasis in Aging and Neurodegenerative Disease

• Published in: Cell reports (Cambridge) Vol. 9; no. 3; pp. 1135 - 1150
• Main Authors: Brehme, Marc, Voisine, Cindy, Rolland, Thomas, Wachi, Shinichiro, Soper, James H, Zhu, Yitan, Orton, Kai, Villella, Adriana, Garza, Dan, Vidal, Marc, Ge, Hui, Morimoto, Richard I
• Format: Journal Article
• Language: English
• Published: 23.10.2014
• ISSN: 2211-1247
• DOI: 10.1016/j.celrep.2014.09.042

Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and expression datasets. During human brain aging, e...