A miRNA upregulated in asthma airway T cells promotes TH2 cytokine production

• Published in: Nature immunology Vol. 15; no. 12; pp. 1162 - 1170
• Main Authors: Simpson, Laura J., Patel, Sana, Bhakta, Nirav R., Choy, David F., Brightbill, Hans D., Ren, Xin, Wang, Yanli, Pua, Heather H., Baumjohann, Dirk, Montoya, Misty M., Panduro, Marisella, Remedios, Kelly A., Huang, Xiaozhu, Fahy, John V., Arron, Joseph R., Woodruff, Prescott G., Ansel, Karl M.
• Format: Journal Article
• Language: English
• Published: 02.11.2014

MicroRNAs (miRNAs) exert powerful effects on immune function by tuning networks of target genes that orchestrate cell behavior. We sought to uncover miRNAs and miRNA-regulated pathways that control the T H 2 responses that drive pathogenic inflammation in asthma. Profiling miRNA expression in human...