A miRNA upregulated in asthma airway T cells promotes TH2 cytokine production
MicroRNAs (miRNAs) exert powerful effects on immune function by tuning networks of target genes that orchestrate cell behavior. We sought to uncover miRNAs and miRNA-regulated pathways that control the T H 2 responses that drive pathogenic inflammation in asthma. Profiling miRNA expression in human...
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| Published in | Nature immunology Vol. 15; no. 12; pp. 1162 - 1170 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
02.11.2014
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| Online Access | Get full text |
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| Abstract | MicroRNAs (miRNAs) exert powerful effects on immune function by tuning networks of target genes that orchestrate cell behavior. We sought to uncover miRNAs and miRNA-regulated pathways that control the T
H
2 responses that drive pathogenic inflammation in asthma. Profiling miRNA expression in human airway-infiltrating T cells revealed miR-19a elevation in asthma. Modulating miR-19 activity altered T
H
2 cytokine production in both human and mouse T cells, and T
H
2 cell responses were markedly impaired in cells lacking the entire miR-17∼92 cluster. miR-19 promotes T
H
2 cytokine production and amplifies PI(3)K, JAK-STAT, and NF-κB signaling by direct targeting of PTEN, SOCS1, and A20. Thus, miR-19a up regulation in asthma may be an indicator and a cause of increased T
H
2 cytokine production in the airways. |
|---|---|
| AbstractList | MicroRNAs (miRNAs) exert powerful effects on immune function by tuning networks of target genes that orchestrate cell behavior. We sought to uncover miRNAs and miRNA-regulated pathways that control the T
H
2 responses that drive pathogenic inflammation in asthma. Profiling miRNA expression in human airway-infiltrating T cells revealed miR-19a elevation in asthma. Modulating miR-19 activity altered T
H
2 cytokine production in both human and mouse T cells, and T
H
2 cell responses were markedly impaired in cells lacking the entire miR-17∼92 cluster. miR-19 promotes T
H
2 cytokine production and amplifies PI(3)K, JAK-STAT, and NF-κB signaling by direct targeting of PTEN, SOCS1, and A20. Thus, miR-19a up regulation in asthma may be an indicator and a cause of increased T
H
2 cytokine production in the airways. |
| Author | Simpson, Laura J. Wang, Yanli Fahy, John V. Brightbill, Hans D. Choy, David F. Ren, Xin Remedios, Kelly A. Ansel, Karl M. Pua, Heather H. Panduro, Marisella Baumjohann, Dirk Huang, Xiaozhu Montoya, Misty M. Woodruff, Prescott G. Arron, Joseph R. Patel, Sana Bhakta, Nirav R. |
| AuthorAffiliation | 6 Department of Pathology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143 USA 1 Department of Microbiology & Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143 USA 5 Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 USA 3 Immunology, Tissue Growth, and Repair Biomarker Discovery, Genentech, South San Francisco, CA 94080 USA 4 Department of Immunology, Genentech, South San Francisco, CA 94080 USA |
| AuthorAffiliation_xml | – name: 6 Department of Pathology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143 USA – name: 1 Department of Microbiology & Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143 USA – name: 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 USA – name: 3 Immunology, Tissue Growth, and Repair Biomarker Discovery, Genentech, South San Francisco, CA 94080 USA – name: 4 Department of Immunology, Genentech, South San Francisco, CA 94080 USA – name: 5 Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA |
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University of California San Francisco, San Francisco, CA 94143 USA Department of Pathology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143 USA – sequence: 6 givenname: Xin surname: Ren fullname: Ren, Xin organization: Department of Microbiology & Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143 USA Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 USA Immunology, Tissue Growth, and Repair Biomarker Discovery, Genentech, South San Francisco, CA 94080 USA Department of Immunology, Genentech, South San Francisco, CA 94080 USA Lung Biology Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 USA Department of Pathology, Sandler Asthma Basic Research Center, University of California San Francisco, San 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| Snippet | MicroRNAs (miRNAs) exert powerful effects on immune function by tuning networks of target genes that orchestrate cell behavior. We sought to uncover miRNAs and... |
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| Title | A miRNA upregulated in asthma airway T cells promotes TH2 cytokine production |
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