CS-17UPREGULATION OF THE ENDOPLASMIC RETICULUM CHAPERONE, PROLYL 4-HYDROXYLASE, BETA POLYPEPTIDE (P4HB) PROMOTES INVASION, ANGIOGENESIS AND GROWTH VIA EGFR/MAPK (ERK) SIGNALLING PATHWAY IN MALIGNANT GLIOMA

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 16; no. Suppl 5; p. v54
• Main Authors: Leung, Gilberto K.K., Sun, Stella, Ho, Amy S.W., Lee, Derek, Kiang, Karrie M.Y., Xu, Fei-fan, Pu, Jenny K.S., Zhang, Xiao-qin
• Format: Journal Article
• Language: English
• Published: Oxford University Press 01.11.2014
• Subjects: Abstracts

BACKGROUND: Tumor invasion and vascularization are typical hallmarks in malignant glioma with the majority showing elevated expression and activation of the epidermal growth factor receptor (EGFR). Our group has previously shown that prolyl 4-hydroxylase, beta polypeptide (P4HB), an endoplasmic reti...