The RhoA GEF, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration

• Published in: The Journal of immunology (1950) Vol. 192; no. 7; pp. 3390 - 3398
• Main Authors: Lessey-Morillon, Elizabeth C., Osborne, Lukas D., Monaghan-Benson, Elizabeth, Guilluy, Christophe, O’Brien, E. Timothy, Superfine, Richard, Burridge, Keith
• Format: Journal Article
• Language: English
• Published: 28.02.2014

RhoA-mediated cytoskeletal rearrangements in endothelial cells (ECs) play an active role in leukocyte transendothelial cell migration (TEM), a normal physiological process in which leukocytes cross the endothelium to enter the underlying tissue. While much has been learned about RhoA signaling pathw...