A dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor-channel complexes

• Published in: European journal of pharmacology Vol. 718
• Main Authors: Kalappa, Bopanna I., Uteshev, Victor V.
• Format: Journal Article
• Language: English
• Published: 11.09.2013

PNU-120596 (1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea), a Type-II positive allosteric modulator of α7 nicotinic acetylcholine receptors inhibits α7 desensitization and robustly prolongs openings of α7 channels. However, these effects may render α7 channels more accessible to pos...