The novel role of IL-7 ligation to IL-7R in myeloid cells of rheumatoid arthritis and collagen induced arthritis

• Published in: The Journal of immunology (1950) Vol. 190; no. 10; pp. 5256 - 5266
• Main Authors: Chen, Zhenlong, Kim, Seung-jae, Chamberlain, Nathan D., Pickens, Sarah R., Volin, Michael V., Volkov, Suncica, Arami, Shiva, Christman, John W., Prabhakar, Bellur S., Swedler, William, Mehta, Anjali, Sweiss, Nadera, Shahrara, Shiva
• Format: Journal Article
• Language: English
• Published: 19.04.2013

Although role of IL-7 and IL-7R has been implicated in the pathogenesis of Rheumatoid arthritis (RA), the majority of the studies have focused on the impact of IL-7/IL-7R in T cell development and function. Our novel data, however, document that RA patients with greater disease activity have higher...