Competitive but Not Allosteric mTOR Kinase Inhibition Enhances Tumor Cell Radiosensitivity1

• Published in: Translational oncology Vol. 6; no. 3; pp. 355 - 362
• Main Authors: Hayman, Thomas J, Kramp, Tamalee, Kahn, Jenna, Jamal, Muhammad, Camphausen, Kevin, Tofilon, Philip J
• Format: Journal Article
• Language: English
• Published: Neoplasia Press Inc 01.06.2013

The mechanistic target of rapamycin (mTOR) is a critical kinase in the regulation of gene translation and has been suggested as a potential target for radiosensitization. The goal of this study was to compare the radiosensitizing activities of the allosteric mTOR inhibitor rapamycin with that of the...