Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photodimers

• Published in: Bioorganic & medicinal chemistry Vol. 20; no. 4; pp. 1482 - 1493
• Main Authors: McCracken, Stephen T., Kaiser, Marcel, Boshoff, Helena I., Boyd, Peter D. W., Copp, Brent R.
• Format: Journal Article
• Language: English
• Published: 02.01.2012

Previous studies have identified the 3,6-dialkyl-4-hydroxy-pyran-2-one marine microbial metabolites pseudopyronines A and B to be modest growth inhibitors of Mycobacterium tuberculosis and a range of tropical diseases including Plasmodium falciparum and Leishmania donovani . In an effort to expand t...