The application of 23Na DQF NMR spectroscopy for the study of spinal disc degeneration
Degenerative disc disease is an irreversible process that leads to a loss of mechanical integrity and back pain in millions of people. In this report, 23 Na DQF NMR spectroscopy is used to study disc tissues in two stages of degeneration. Initial results indicate that the 23 Na DQF signal may be use...
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| Published in | Magnetic resonance in medicine Vol. 60; no. 2; pp. 246 - 252 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.08.2008
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| Online Access | Get full text |
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| Abstract | Degenerative disc disease is an irreversible process that leads to a loss of mechanical integrity and back pain in millions of people. In this report,
23
Na DQF NMR spectroscopy is used to study disc tissues in two stages of degeneration. Initial results indicate that the
23
Na DQF signal may be useful for determining the degree of degeneration. The spectral analysis reveals the presence of sodium environments with different residual quadrupolar couplings and T
2
relaxation times that we attribute to different regions, or compartments, corresponding to different biochemical regions in the tissue. In general it is found that there are compartments with no residual quadrupolar couplings, compartments with moderate couplings, 200 to 1000 Hz, and compartments with couplings ranging from 1500 to 3000 Hz. The results indicate that
23
Na DQF NMR spectroscopy provides a probe of the degenerative state of the intervertebral disc tissues, and might hold potential as a novel diagnostic method for detection of disc degeneration. |
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| AbstractList | Degenerative disc disease is an irreversible process that leads to a loss of mechanical integrity and back pain in millions of people. In this report,
23
Na DQF NMR spectroscopy is used to study disc tissues in two stages of degeneration. Initial results indicate that the
23
Na DQF signal may be useful for determining the degree of degeneration. The spectral analysis reveals the presence of sodium environments with different residual quadrupolar couplings and T
2
relaxation times that we attribute to different regions, or compartments, corresponding to different biochemical regions in the tissue. In general it is found that there are compartments with no residual quadrupolar couplings, compartments with moderate couplings, 200 to 1000 Hz, and compartments with couplings ranging from 1500 to 3000 Hz. The results indicate that
23
Na DQF NMR spectroscopy provides a probe of the degenerative state of the intervertebral disc tissues, and might hold potential as a novel diagnostic method for detection of disc degeneration. |
| Author | Marcolongo, Michele Polenova, Tatyana Ooms, Kristopher J. Cannella, Marco Vega, Alexander J. |
| AuthorAffiliation | 2 Department of Materials Science and Engineering, LeBow 27-444, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 1 Department of Chemistry and Biochemistry, 112 Lammot DuPont Laboratories, University of Delaware, Newark, DE 19716 |
| AuthorAffiliation_xml | – name: 1 Department of Chemistry and Biochemistry, 112 Lammot DuPont Laboratories, University of Delaware, Newark, DE 19716 – name: 2 Department of Materials Science and Engineering, LeBow 27-444, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 |
| Author_xml | – sequence: 1 givenname: Kristopher J. surname: Ooms fullname: Ooms, Kristopher J. organization: Department of Chemistry and Biochemistry, 112 Lammot DuPont Laboratories, University of Delaware, Newark, DE 19716 Department of Materials Science and Engineering, LeBow 27-444, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 – sequence: 2 givenname: Marco surname: Cannella fullname: Cannella, Marco organization: Department of Chemistry and Biochemistry, 112 Lammot DuPont Laboratories, University of Delaware, Newark, DE 19716 Department of Materials Science and Engineering, LeBow 27-444, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 – sequence: 3 givenname: Alexander J. surname: Vega fullname: Vega, Alexander J. organization: Department of Chemistry and Biochemistry, 112 Lammot DuPont Laboratories, University of Delaware, Newark, DE 19716 Department of Materials Science and Engineering, LeBow 27-444, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 – sequence: 4 givenname: Michele surname: Marcolongo fullname: Marcolongo, Michele organization: Department of Chemistry and Biochemistry, 112 Lammot DuPont Laboratories, University of Delaware, Newark, DE 19716 Department of Materials Science and Engineering, LeBow 27-444, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 – sequence: 5 givenname: Tatyana surname: Polenova fullname: Polenova, Tatyana organization: Department of Chemistry and Biochemistry, 112 Lammot DuPont Laboratories, University of Delaware, Newark, DE 19716 Department of Materials Science and Engineering, LeBow 27-444, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104 |
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| Snippet | Degenerative disc disease is an irreversible process that leads to a loss of mechanical integrity and back pain in millions of people. In this report,
23
Na... |
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| Title | The application of 23Na DQF NMR spectroscopy for the study of spinal disc degeneration |
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