Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load1

• Published in: The Journal of immunology (1950) Vol. 187; no. 5; pp. 2222 - 2232
• Main Authors: Day, Cheryl L., Abrahams, Deborah A., Lerumo, Lesedi, van Rensburg, Esme Janse, Stone, Lynnett, O’rie, Terrence, Pienaar, Bernadette, de Kock, Marwou, Kaplan, Gilla, Mahomed, Hassan, Dheda, Keertan, Hanekom, Willem A.
• Format: Journal Article
• Language: English
• Published: 20.07.2011

High antigen load in chronic viral infections has been associated with impairment of antigen-specific T cell responses; however, the relationship between antigen load in chronic Mycobacterium tuberculosis ( Mtb ) infection and functional capacity of Mtb -specific T cells in humans is not clear. We c...