β1 INTEGRIN IS CRITICAL FOR THE MAINTENANCE OF ANTIGEN-SPECIFIC CD4 T CELLS IN THE BONE MARROW BUT NOT LONG-TERM IMMUNOLOGICAL MEMORY1
The long-term maintenance of memory CD4 T cells promotes protective immunity against future pathogen re-infection. As a site rich in survival cytokines, the bone marrow is proposed to be a critical niche for the survival of memory CD4 T cells. We demonstrate that endogenous, polyclonal Ag-specific C...
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Published in | The Journal of immunology (1950) Vol. 186; no. 7; pp. 4019 - 4026 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
25.02.2011
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Online Access | Get full text |
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Abstract | The long-term maintenance of memory CD4 T cells promotes protective immunity against future pathogen re-infection. As a site rich in survival cytokines, the bone marrow is proposed to be a critical niche for the survival of memory CD4 T cells. We demonstrate that endogenous, polyclonal Ag-specific CD4 T cells rapidly enter and are recovered long-term from the bone marrow following intravenous infection with
Listeria monocytogenes
. β1 integrin-deficient CD4 T cells also populate the bone marrow early following an infection, but their numbers in this site rapidly decline. This decline was not caused by increased death of T cells lacking β1 integrin but rather by reduced retention in the bone marrow after the primary immune response. The loss of memory CD4 T cells from the bone marrow does not lead to a loss of the predominant source of memory CD4 T cells in the spleen or the ability to mount a memory response. Thus, β1 integrin-dependent maintenance of memory CD4 T cells in the bone marrow is not required for long-term CD4 T cell memory. |
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AbstractList | The long-term maintenance of memory CD4 T cells promotes protective immunity against future pathogen re-infection. As a site rich in survival cytokines, the bone marrow is proposed to be a critical niche for the survival of memory CD4 T cells. We demonstrate that endogenous, polyclonal Ag-specific CD4 T cells rapidly enter and are recovered long-term from the bone marrow following intravenous infection with
Listeria monocytogenes
. β1 integrin-deficient CD4 T cells also populate the bone marrow early following an infection, but their numbers in this site rapidly decline. This decline was not caused by increased death of T cells lacking β1 integrin but rather by reduced retention in the bone marrow after the primary immune response. The loss of memory CD4 T cells from the bone marrow does not lead to a loss of the predominant source of memory CD4 T cells in the spleen or the ability to mount a memory response. Thus, β1 integrin-dependent maintenance of memory CD4 T cells in the bone marrow is not required for long-term CD4 T cell memory. |
Author | Shimizu, Yoji DeNucci, Christopher C. |
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Title | β1 INTEGRIN IS CRITICAL FOR THE MAINTENANCE OF ANTIGEN-SPECIFIC CD4 T CELLS IN THE BONE MARROW BUT NOT LONG-TERM IMMUNOLOGICAL MEMORY1 |
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