Nicotinamide-independent asymmetric bioreduction of C Created by potrace 1.16, written by Peter Selinger 2001-2019 C-bonds via disproportionation of enones catalyzed by enoate reductases

The asymmetric bioreduction of activated C C-bonds catalyzed by a single flavoprotein was achieved via direct hydrogen transfer from a sacrificial 2-enone or 1,4-dione as hydrogen donor without requirement of a nicotinamide cofactor. Due to its simplicity, this system has clear advantages over conve...

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Published inTetrahedron Vol. 66; no. 3-2; pp. 663 - 667
Main Authors Stueckler, Clemens, Reiter, Tamara C., Baudendistel, Nina, Faber, Kurt
Format Journal Article
LanguageEnglish
Published Pergamon Press 16.01.2010
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Summary:The asymmetric bioreduction of activated C C-bonds catalyzed by a single flavoprotein was achieved via direct hydrogen transfer from a sacrificial 2-enone or 1,4-dione as hydrogen donor without requirement of a nicotinamide cofactor. Due to its simplicity, this system has clear advantages over conventional FAD-recycling systems.
ISSN:0040-4020
0040-4020
DOI:10.1016/j.tet.2009.11.065